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-synuclein, which can be a most important part of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, and that is an E3 ubiquitin ligase and will cause endoplasmic reticulum (ER) stress, counsel that dysfunction with the intracellular proteinase systems, including ubiquitin-proteasome technique or lysosomal system, which gets rid of poin